We pick our top pop culture dynamic duos, from Thelma and Louise to Bill and Ted.
Here are our 25 favorite pairs of fictional best friends from movies and TV.
Thelma (Geena Davis) and Louise (Susan Sarandon) keep going.M.S.

EW’s favorite pairs of fictional best friends.Credit:Buena Vista Pictures/courtesy Everett Collection; Colleen Hayes/NBCU Photo Bank/NBCUniversal via Getty; New Line/courtesy Everett Collection
Nor could anyone ever be a better pal to Leslie than Ann, opalescent tree shark.
Stay glam!M.S.
That’s what it means to be someone’s person.M.S.

Alex Winter and Keanu Reeves in ‘Bill & Ted’s Excellent Adventure’.Everett Collection
She keeps Mia’s (Anne Hathaway) royal secret!
Do you know how hard it is to have a cable show and keep a secret?M.S.
‘Don’t you leave him, Samwise Gamgee.’

Susan Sarandon and Geena Davis in ‘Thelma & Louise’.Everett Collection
And I don’t mean to.
I don’t mean to.“M.S.
Why don’t they say that every day?

Rashida Jones and Amy Poehler on ‘Parks and Recreation’.NBC
Why can’t they say it more often?M.S.
Turk and J.D.
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This pair of besties (Zach BraffandDonald Faison) practically invented the TV bromance.

Woody (Tom Hanks) and Buzz Lightyear (Tim Allen) in ‘Toy Story’.Disney/Pixar
Now EEEEEAGLEEEE!M.S.

Mike Myers and Dana Carvey in ‘Wayne’s World’.Everett

Jennifer Saunders and Joanna Lumley on ‘Absolutely Fabulous’.Everett Collection

Anthony Edwards and Tom Cruise on ‘Top Gun’.Paramount Pictures

Saoirse Ronan and Beanie Feldstein in ‘Lady Bird’.Everett

Stacey Dash and Alicia Silverstone in ‘Clueless’.Everett Collection

Pumbaa (Ernie Sabella) and Timon (Nathan Lane) in ‘The Lion King’.Everett Collection

Sandra Oh and Ellen Pompeo on ‘Grey’s Anatomy’.Eric McCandless/ABC/Getty Images

Matt LeBlanc and Matthew Perry on ‘Friends’.Mike Ansell/NBC/NBCU Photo Bank/Getty Images

Brad Pitt and Leonardo DiCaprio in ‘Once Upon a Time in Hollywood’.Everett

Vivian Vance and Lucille Ball on ‘I Love Lucy’.CBS Photo Archive/Getty Images

Patrick Star and SpongeBob SquarePants in ‘The SpongeBob SquarePants Movie’.Everett Collection

Heather Matarazzo and Anne Hathaway in ‘The Princess Diaries’.Everett Collection

Sean Astin and Elijah Wood in ‘The Lord of the Rings: The Two Towers’.Everett Collection

Lisa Kudrow and Mira Sorvino in ‘Romy and Michele’s High School Reunion’.Buena Vista Pictures/Everett Collection

Shaggy Rogers and Scooby-Doo of ‘Scooby-Doo’.Everett Collection

Jane Russell and Marilyn Monroe in ‘Gentlemen Prefer Blondes’.20th Century Fox/Kobal/REX/Shutterstock

Michael Cera and Jonah Hill in ‘Superbad’.Everett Collection

Beanie Feldstein and Kaitlyn Dever in ‘Booksmart’.Everett

Bette Midler and Barbara Hershey in ‘Beaches’.Everett Collection

Zach Braff and Donald Faison on ‘Scrubs’.Chris Haston/NBCU Photo Bank/GETTY IMAGES

Josh O’Connor and Mike Faist in ‘Challengers’.Everett