Applegate was diagnosed with multiple sclerosis in 2021, while Sigler was diagnosed decades ago.
Christina Applegatetook the stage at the 2024Emmysto aloud standing ovation.
Now, the beloved actress.

Christina Applegate and Jamie-Lynn Sigler.Gilbert Flores/Variety via Getty Images; Scott Gries/BRAVO via Getty Images
“We haven’t stopped talking since,” Applegate added.
“We have each other, and that’s helped us so much.”
Let’s record this.
Let’s do it,'" Applegate said.
We are sharing the deepest parts of ourselves."
The podcast won’t only feature the pair of actresses.
Upcoming episodes will include friends and former costars likeMartin ShortandEdie Falco, per PEOPLE.