Emma McIntyre/Getty

Christina Applegateis being radically transparent about the pain and suffering triggered by multiple sclerosis.

“That is unimaginable, okay?

And literally just in the last month, I have figured it out.”

Christina Applegate and James Corden appear on SiriusXM’s ‘This Life Of Mine with James Corden’ at SiriusXM Studios on April 08, 2024 in Los Angeles, California

Christina Applegate in 2024.Credit:Emma McIntyre/Getty

But she urged the listener, “Talk to your doctor about motility issues, okay?

Because one of the things with MS is that it slows down our organs.

Not completely, but there is a slowing of the function of your organs.

Christina Applegate in Dead to Me

Christina Applegate in ‘Dead to Me’.Courtesy of Netflix

And when I puke, I get all the pain, and then all the things happen.

It’s like everyone’s fighting with each other.

So like ask your doctor about that.”

Courtesy of Netflix

Applegate revealed in August 2021 that she wasdiagnosed with MSearlier that year.

“It’s been a tough road.

Because that’s my favorite part.

That’s the sexiest part.”

Sigler told her it was called “the double dragon…

Diarrhea out of your butt and puke out of your mouth.

You’re double dragoning.”

“Well, always have a little trash can next to your toilet.

Because it’s possible for you to do both without it being messy.”

Listen to the rest of Tuesday’s episode ofMeSsybelow.