Catch up with Ellen Pompeo, Patrick Dempsey, and more of your favorite stars throughout the years.
One thing all viewers appreciate, however, is the shows amazing cast and its colorful characters.
TheGreys Anatomycast has gone through many changes since the series debuted in 2005.

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Thats all thanks toGreys Anatomy, where she played the titular character Dr. Meredith Grey.
I just love them.
Pompeo has been part ofGreys Anatomysince its start in 2005.

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For a while, it looked like she might never cease her full-time commitment to the show.
She began appearing in fewer episodes by season 19, though she still provided voiceovers.
Her character will stillappear in four episodesof the upcoming 20th season.

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This is my set.
Who are you telling?
She was later met with media scrutiny over her attitude towards Washington.

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The actor married music producer Chris Ivery in 2007.
Fans will always remember when his character was shockingly killed off in season 11.
I knew it would be heavy like that.

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I didnt realize untilwe did our interviewthat it was really over, he said.
He later married Jillian Fink in 1999, with whom he shares three children.
The couple nearly divorced in 2015, but they reconciled the following year.

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Oh played the hard worker and fierce friend of Meredith Grey for 10 seasons.
Even after Oh leftGreys Anatomyin 2014, fans still wondered if she would ever return.
It means a lot to me.

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She also racked up a whopping 11 Emmy nominations between the two shows.
Oh was previously married to directorAlexander Payne(The Holdovers) from 2003 to 2006.
Pickens Jr. is married to former Musique member Gina Taylor, with whom he shares two children.

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Its not even anxiety.
Its just the reality of what we do.
I never get so comfortable that I ever forget that,Wilson told EW in 2010.

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What we do as actors is really about decisions that get made in rooms with desks.
And people change their minds all the time about things…
So you make the most of it and you learn as much as you’re able to.

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Wilson continues to star inGreys Anatomyand the spinoffStation 19.
Her character also appeared in two episodes ofPrivate Practicein 2009.
She has three children with her longtime partner.

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She is also an advocate for treating substance abuse and mental health disorders.
She joined theGreys Anatomycast in 2005 as Dr. Izzie Stevens.
This led to a public perception that Heigl was a diva.

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She left the series shortly thereafter in season 6 and later expressed regrets about the ordeal.
I am disappointed in myself for allowing that perception to exist,she told EW.
She also starred in and produced NetflixsFirefly Lane(20212023).

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Shell soon star in the filmThats Amoreopposite John Travolta.
Heigl married singer Josh Kelley in 2007.
Two of their three children are adopted.

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Heigl has received awards for her activism surrounding adoption, animal welfare, and cancer awareness.
They followed this success with an 11-season stint as Dr. Callie Torres, an orthopedic resident turned attending surgeon.
Dr. Torres thus became an early marker of queer representation on primetime television.

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I will always have a soft tender place in my heart for that work family and that role.
It was the role of a lifetime."
They also lent their voice to DisneysSofia the Firstfrom 2012 to 2018.

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Ramirez married Ryan DeBolt in 2012.
The couple later separated in 2021.
I loved doingGreys Anatomy.

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I would have done it until the final episode, but this was something I couldnt pass up.
The actor has since made waves by playing the complicated and sinister Cal Jacobs on HBOsEuphoria(2019present).
He will also appear in the upcoming filmsBorderlineandBad Boys 4.
Danemarried actress Rebecca Gayheartin 2004.
They have two children together.
She later filed for divorce in 2018.
She also has a dizzying relationship with Eric Danes Mark Sloan throughout her tenure.
“To be part of that was obviously very special,Leigh told PEOPLE in 2021.
Kind of bring a little life back to it…
It was a special experience to be able to be part of that.”
The actress biggest role post-Greyshas been playing Alex Danvers on the CW dramaSupergirl(20152021).
As the titular heroines sister, she also appeared in other Arrowverse shows likeLegends of TomorrowandThe Flash.
She currently stars in and produces the Hallmark Channel seriesThe Way Home.
Leigh has been married to Nathan West since 2002.
They have three children together.
Chambers carried the role for 14 years, which is no small feat.
I like having a job.
I like the people I work with.
My boss is awesome.
Ive got nowhere better to be.
This is where Im supposed to be, and Im enjoying it.
Eventually, Chambersdidhave somewhere better to be.
After leavingGreys Anatomyin 2020, he portrayedMarlon Brandoin the Paramount+ miniseriesThe Offer(2022).
Hes been married to former model agency booker Keisha Chambers since 1993.
They have five children together.
“There are a lot of people who would like to be in my position.
But in the end, I need to be fulfilled in my work.”
Hes since starred inThe Flight Attendant(20202022) alongside Kaley Cuoco.
Knight has been married to dancer Patrick B. Leahy since 2013.
She began starring in the medical drama in 2005 as neonatal surgeon Dr. Addison Montgomery.
That runaway success might have surprised some actors, but not Walsh.
Shetold PEOPLE in 2021that she had a premonition thatGreys Anatomywas destined for greatness.
Sometimes I do feel like I get a little witchy about things," she said.
“I was like, ‘This is a great show.’
Even before it even had an airtime…And here we are…
It definitely changed my life.”
In many ways, Addison was a character that Walsh just couldnt quit.
She stopped appearing regularly onGreys Anatomyafter season 3, though she still returned for occasional episodes.
In 2021, she officially rejoined theGreyscast in a guest starring role.
Walsh was married to Alex Young from 2007 to 2010.
She is currently engaged to Andrew Nixon, whom shemet on an exciting expeditionto the Antarctic.
ButGreys Anatomyhas been his biggest project to date.
Hes a good guy.
But we realized pretty quickly that there was a lot there.
He has two children from each marriage and is currentlydating actress Danielle Savre.
The writers always have storylines that are so surprising and change everything.
There’s no element of, Ugh, how do I keep this interesting for myself?"
When I started off, I was dating my now husband.
It’s like growing with a buddy.
That’s the surprising part of the experience, when you sit with somebody for that long.
You’re so invested.
Luddington married Matthew Alan in 2019, and as the actor noted, they are raising two children together.
Fans were surprised when Capshaws character lost a leg, as was the actor herself.
It was something Id never even pondered, which is why shes the master storyteller.
It took me a while to wrap my head around.
The actor married Christopher Gavigan in 2004.
They have four children together.
She is the stepdaughter of directorSteven Spielberg.
Dressup orPower Play).
Whats more, the character has been a fixture on the spinoffStation 19since 2018.
Scorsone was married to Rob Giles from 2009 to 2020.