The Missouri-born actress first appeared as Monica Quartermaine on the long-running daytime drama in 1977.

Albert L. Ortega/Getty

Leslie Charleson, best known for her long-time role onGeneral Hospital, has died.

12 postaccompanied by words from executive producer Frank Valenti.

Leslie Charleson arrives for the 88th Annual Hollywood Christmas Parade held on December 1, 2019 in Hollywood, California.

Leslie Charleson in 2019.Credit:Albert L. Ortega/Getty

Valenti continued, “I will miss our daily chats, her quick wit and incredible presence on set.

Charleson was first cast as Monica Quartermaine onGeneral Hospitalin 1977.

She remained on the cast of theABCmainstay until December 2023, making her the longest-tenured actor on the series.

LESLIE CHARLESON GENERAL HOSPITAL

Genie Francis, Leslie Charleson, and Caitlin Reilly on ‘General Hospital’.Todd Wawrychuk/ABC via Getty

She has also slapped half of the women of Port Charles.

Monica’s breast cancer arc from 1994-2000 remains one of the most harrowing and impactful sagas in recentGeneral Hospitalhistory.

My mother had it,” Charleson told costar Maurice Benard in a2022 interview.